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KMID : 0616119960270010047
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Korean Journal of Pharmacognosy
1996 Volume.27 No. 1 p.47 ~ p.52
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The Effects of Meliae toosendan Fructus on Liver Function III. - Effects of Melianone and 28-Deacetyl Sendanin on Drug Metabolism and Bile Juice Secretion -
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Kim Bu-Saeng
Kim Hye-Kyung
Choi Jong-Won
Lee Chung-Kyu
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Abstract
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A triterpenoid(melianone) and a limonoid(28-deacetyl sendanin) were isolated from the chloroform fraction of Meliae toosendan Fructus, the rippen fruits of Melia toosendan SIEB. et ZUCC. (Meliaceae) and were applied to serial experiments to clarify the liver protective activities. We found that the compounds promoted slightly the drug metabolizing enzyme activities and decreased serum transaminase activities which was elevated by carbon tetrachloride intoxication. And also they slightly increased the secretion of bile juice in rat.
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KEYWORD
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Medlia toosendan, Meliaceae, melianone, 28-edacetyl sendanin, liver protective activity
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